Ubiquitination: RING for destruction?

Authors
Freemont, PS
Citation
Ps. Freemont, Ubiquitination: RING for destruction?, CURR BIOL, 10(2), 2000, pp. R84-R87
Citations number
20
Categorie Soggetti
Experimental Biology
Journal title
CURRENT BIOLOGY
ISSN journal
09609822 → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
R84 - R87
Database
ISI
SICI code
0960-9822(20000127)10:2<R84:URFD>2.0.ZU;2-W
Abstract
Ubiquitination targets proteins for degradation and is a potent regulator o f cellular protein function. Recent results implicate the RING finger domai n in specific ubiquitination events; it is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a variety of bio logical areas.