SYNTHESIS OF ENANTIOMERICALLY PURE CIS AND TRANS 2-AMINOCYCLOPENTANECARBOXYLIC ACIDS - USE OF PROLINE REPLACEMENTS IN POTENTIAL HIV-PROTEASE INHIBITORS

Authors
NOTEBERG D BRANALT J KVARNSTROM I CLASSON B SAMUELSSON B NILLROTH U DANIELSON H KARLEN A HALLBERG A
Citation
D. Noteberg et al., SYNTHESIS OF ENANTIOMERICALLY PURE CIS AND TRANS 2-AMINOCYCLOPENTANECARBOXYLIC ACIDS - USE OF PROLINE REPLACEMENTS IN POTENTIAL HIV-PROTEASE INHIBITORS, Tetrahedron, 53(23), 1997, pp. 7975-7984
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
23
Year of publication
1997
Pages
7975 - 7984
Database
ISI
SICI code
0040-4020(1997)53:23<7975:SOEPCA>2.0.ZU;2-0
Abstract
The synthesis of the four diastereomeric 2-aminocyclopentanecarboxylic acids, their use as replacements for proline in potential HIV proteas e inhibitors containing a hydroxyethylamine dipeptide isostere and the evaluation of the biological activity of these is described. (C) 1997 Elsevier Science Ltd.