Drug interactions are a common and serious problem arising from polypharmac
y. Strategies to reduce the likelihood of the co-prescription of hazardous
drug combinations are likely to enhance the quality of care provided for pa
tients requiring polypharmacotherapy. Drugs for which patient-oriented info
rmation strategies may decrease the likelihood of drug interactions tend to
be those of low therapeutic index, and have interaction potential with oth
er drugs commonly prescribed or available without prescription.