Capillary electrophoresis of peptides

This article gives a review of the recent developments in capillary electro phoresis (CE) of peptides. New approaches to the theoretical description of electromigration behavior of peptides are described, and methodological as pects of CE separations of peptides such as selection of separation conditi ons, sample treatment, suppression of peptide adsorption to the capillary w all and specificities of CE separation modes are discussed. Progress in app lication of high performance detection schemes, namely laser-induced fluore scence and mass spectrometry, in peptide separations by CE is presented. Ap plications of different CE techniques, zone electrophoresis, isotachophores is, isoelectric focusing, affinity electrophoresis, electrokinetic chromato graphy and electrochromatography to peptide analysis, preparation and physi cochemical characterization are demonstrated.