Vinylpyrrolidine-beta-cyclodextrin copolymer: A novel chiral selector for capillary electrophoresis

The synthesis and characterization of a novel polymer consisting of an alky l backbone and pendant beta-cyclodextrin units, obtained by radical copolym erization of vinylpyrrolidone and methacryloyl-beta-cyclodextrin (PVP-beta- CD), was reported. The ability of this copolymer to act as a capillary elec trophoresis (CE) chiral selector was investigated in the separation of a mi xture of basic drugs. The influence of polymeric cyclodextrin concentration , temperature, and pH on the separation of the test analytes was assessed a nd the advantage of using the polymeric selector over native beta-cyclodext rin was demonstrated.