Comparison of highly sulfated alpha-, beta-, and gamma-cyclodextrins and 18-crown-6-tetracarboxylic acid for the enantiomeric separation of some amino acids and derivatives by capillary electrophoresis

Authors
Verleysen, K Van den Bosch, T Sandra, P
Citation
K. Verleysen et al., Comparison of highly sulfated alpha-, beta-, and gamma-cyclodextrins and 18-crown-6-tetracarboxylic acid for the enantiomeric separation of some amino acids and derivatives by capillary electrophoresis, ELECTROPHOR, 20(13), 1999, pp. 2650-2655
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
ELECTROPHORESIS
ISSN journal
01730835 → ACNP
Volume
20
Issue
13
Year of publication
1999
Pages
2650 - 2655
Database
ISI
SICI code
0173-0835(199909)20:13<2650:COHSAB>2.0.ZU;2-U
Abstract
18-Crown-6-tetracarboxylic acid (18C6H(4)) and highly sulfated cyclodextrin s (HS-alpha-, beta-, gamma-CDs) are highly selective chiral selectors for t he enantioseparation of solutes bearing the primary amino function. Excelle nt resolutions were obtained for all solutes on HS-gamma-CD and on 18C6H(4) . The former, however, is by far the best chiral selector for the solutes s tudied in this work because the highest resolution is obtained with the sho rtest migration times. The reversal of the D- and L-migration order on HS-C Ds compared to 18C6H(4) is an interesting feature for the determination of enantiomeric excess.