M. Fillet et al., Designed combination of chiral selectors for adjustment of enantioseparation selectivity in capillary electrophoresis, ELECTROPHOR, 20(13), 1999, pp. 2691-2697
In this study an attempt has been made to explain the reasons for changing
the enantioseparation selectivity in some dual cyclodextrin (CD) systems co
mpared to the use of single chiral selectors in capillary electrophoresis (
CE). An explanation for selectivity changes is proposed based on the effect
of the chiral selector on the mobility of the analyte. In order to support
the proposed mechanism, several dual systems were designed on the basis of
the known recognition pattern of enantiomers for individual CDs. In most c
ases the separation selectivity could be adjusted in a designed way. There
was no experimental evidence for simultaneous binding of a given chiral ana
lyte with both chiral selectors or of chiral recognition of an analyte comp
lex with one CD by another CD.