Designed combination of chiral selectors for adjustment of enantioseparation selectivity in capillary electrophoresis

In this study an attempt has been made to explain the reasons for changing the enantioseparation selectivity in some dual cyclodextrin (CD) systems co mpared to the use of single chiral selectors in capillary electrophoresis ( CE). An explanation for selectivity changes is proposed based on the effect of the chiral selector on the mobility of the analyte. In order to support the proposed mechanism, several dual systems were designed on the basis of the known recognition pattern of enantiomers for individual CDs. In most c ases the separation selectivity could be adjusted in a designed way. There was no experimental evidence for simultaneous binding of a given chiral ana lyte with both chiral selectors or of chiral recognition of an analyte comp lex with one CD by another CD.