Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain

Authors
Gerber, CM Cottagnoud, M Neftel, KA Tauber, MG Cottagnoud, P
Citation
Cm. Gerber et al., Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain, EUR J CL M, 18(12), 1999, pp. 866-870
Citations number
26
Categorie Soggetti
Microbiology
Journal title
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
ISSN journal
09349723 → ACNP
Volume
18
Issue
12
Year of publication
1999
Pages
866 - 870
Database
ISI
SICI code
0934-9723(199912)18:12<866:MAAICW>2.0.ZU;2-X
Abstract
In a rabbit model of meningitis caused by a pneumococcus highly resistant t o penicillin (MIC, 4 mu g/ml), meropenem, a broad-spectrum carbapenem, was bactericidal (-0.48 +/- 0.14 Delta log(10) cfu/ml . h) and slightly superio r to ceftriaxone (-0.34 +/- 0.23 Delta log(10) cfu/ml . h) and vancomycin ( -0.39 +/- 0.19 Delta log(10) cfu/ml . h). Although the combination of vanco mycin with ceftriaxone was significantly more active than ceftriaxone alone (-0.55 +/- 0.19 Delta log(10) cfu/ml . h), only an insignificant gain was observed by the addition of vancomycin to meropenem (-0.55 +/- 0.28 Delta l og(10) cfu/ml . h).