Cm. Gerber et al., Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain, EUR J CL M, 18(12), 1999, pp. 866-870
Citations number
26
Categorie Soggetti
Microbiology
Journal title
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
In a rabbit model of meningitis caused by a pneumococcus highly resistant t
o penicillin (MIC, 4 mu g/ml), meropenem, a broad-spectrum carbapenem, was
bactericidal (-0.48 +/- 0.14 Delta log(10) cfu/ml . h) and slightly superio
r to ceftriaxone (-0.34 +/- 0.23 Delta log(10) cfu/ml . h) and vancomycin (
-0.39 +/- 0.19 Delta log(10) cfu/ml . h). Although the combination of vanco
mycin with ceftriaxone was significantly more active than ceftriaxone alone
(-0.55 +/- 0.19 Delta log(10) cfu/ml . h), only an insignificant gain was
observed by the addition of vancomycin to meropenem (-0.55 +/- 0.28 Delta l
og(10) cfu/ml . h).