Dopamine D-2 receptor ribozyme inhibits quinpirole-induced stereotypy in rats

Authors
Salmi, P Sproat, BS Ludwig, J Hale, R Avery, N Kela, J Wahlestedt, C
Citation
P. Salmi et al., Dopamine D-2 receptor ribozyme inhibits quinpirole-induced stereotypy in rats, EUR J PHARM, 388(1), 2000, pp. R1-R2
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
388
Issue
1
Year of publication
2000
Pages
R1 - R2
Database
ISI
SICI code
0014-2999(20000124)388:1<R1:DDRRIQ>2.0.ZU;2-3
Abstract
The injection of a dopamine D-2 receptor hammerhead ribozyme (20 mu g) once daily for 5 days into the nucleus accumbens of rats resulted in an inhibit ion of stereotyped sniffing and locomotor activation produced by the select ive dopamine D2 receptor agonist, quinpirole (0.4 mg kg(-1) s.c.). The resu lts suggest that ribozymes may be useful in the study of in vivo gene funct ion in the brain. (C) 2000 Elsevier Science B.V. All rights reserved.