S. Lee et al., CONFORMAL RADIOTHERAPY COMPUTATION BY THE METHOD OF ALTERNATING PROJECTIONS ONTO CONVEX-SETS, Physics in medicine and biology, 42(6), 1997, pp. 1065-1086
Synthesis of beam profiles for a given dose prescription is a central
problem in radiotherapy. Care must be taken in the beam design to expo
se the tumour volume at a high level, to avoid significant irradiation
of critical organs, and to minimize exposure of all other tissue. Use
of the synthesis procedure known as alternating projections onto conv
ex sets (POCS) is shown to be a viable approach to beam design. POCS i
s a powerful tool for signal and image restoration and synthesis. Conv
ex sets of signals obeying desired constraint sets are first specified
. Then, by repeated projections onto these sets, convergence is to a s
ignal obeying all desired constraints if the constraint sets have a fi
nite intersection. In this paper we apply the method of POCS to confor
mal radiotherapy dose computation. The performance of the method is sh
own through three representative examples.