Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor

Citation
E. Tiacci et al., Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor, HAEMATOLOG, 85(1), 2000, pp. 94-97
Citations number
18
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
1
Year of publication
2000
Pages
94 - 97
Database
ISI
SICI code
0390-6078(200001)85:1<94:FHEIAR>2.0.ZU;2-3
Abstract
Human herpesvirus-6 (HHV-6), like all the other herpes viruses, remains lat ent in host cells after primary infection but can be reactivated In immuno- compromised patients causing fever, skin rash, bone marrow (BM) suppression , pneumonitis, Sinusitis and meningoencephalitis. We describe the case of a man with chronic myelogenous leukemia who developed encephalitis associate d with acute graft-versus-host disease two months after a T-cell-depleted m ismatched peripheral blood stem cell transplant. Magnetic resonance images of the brain revealed multiple bilateral foci of signal abnormality. HHV-6 was the only pathogen detected in cerebrospinal fluid by PCR. treatment wit h both ganciclovir and foscarnet was unsuccessful and the patient gradually deteriorated and died. Other cases of HHV-6 encephalitis after bone marrow transplantation are reviewed. (C) 2000. Ferrata Storti Foundation.