E. Tiacci et al., Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor, HAEMATOLOG, 85(1), 2000, pp. 94-97
Human herpesvirus-6 (HHV-6), like all the other herpes viruses, remains lat
ent in host cells after primary infection but can be reactivated In immuno-
compromised patients causing fever, skin rash, bone marrow (BM) suppression
, pneumonitis, Sinusitis and meningoencephalitis. We describe the case of a
man with chronic myelogenous leukemia who developed encephalitis associate
d with acute graft-versus-host disease two months after a T-cell-depleted m
ismatched peripheral blood stem cell transplant. Magnetic resonance images
of the brain revealed multiple bilateral foci of signal abnormality. HHV-6
was the only pathogen detected in cerebrospinal fluid by PCR. treatment wit
h both ganciclovir and foscarnet was unsuccessful and the patient gradually
deteriorated and died. Other cases of HHV-6 encephalitis after bone marrow
transplantation are reviewed. (C) 2000. Ferrata Storti Foundation.