Unsuccessful allogeneic and autologous transplants after prolonged interferon-alpha treatment in a pediatric patient with chronic myeloid leukemia

Authors
Perez-Caballero, C Maldonado, MS Tamariz, R de Oteyza, JP Munoz, A
Citation
C. Perez-caballero et al., Unsuccessful allogeneic and autologous transplants after prolonged interferon-alpha treatment in a pediatric patient with chronic myeloid leukemia, HAEMATOLOG, 85(1), 2000, pp. 105-106
Citations number
10
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
1
Year of publication
2000
Pages
105 - 106
Database
ISI
SICI code
0390-6078(200001)85:1<105:UAAATA>2.0.ZU;2-M
Abstract
Recombinant or partially pure human leukocyte interferon-alpha (IFN-alpha) has shown promising activity in the treatment of chronic myeloid leukemia ( CML)(1,2) However, IFN-alpha might inhibit self-renewal of the progenitor c ells in CML3 and may result in irreversible alterations of the marrow micro environment.(4,5) This pediatric case report seems to confirm the negative impact of prolonged IFN-alpha treatment on subsequent stem cell transplanta tion.