SYNTHESIS OF ENANTIOMERICALLY PURE PHOSPHOROTHIOLATE ASSAY SUBSTRATE FOR PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C

Authors
MIHAI C MATAKA J RIDDLE S TSAI MD BRUZIK KS
Citation
C. Mihai et al., SYNTHESIS OF ENANTIOMERICALLY PURE PHOSPHOROTHIOLATE ASSAY SUBSTRATE FOR PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C, Bioorganic & medicinal chemistry letters, 7(10), 1997, pp. 1235-1238
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
10
Year of publication
1997
Pages
1235 - 1238
Database
ISI
SICI code
0960-894X(1997)7:10<1235:SOEPPA>2.0.ZU;2-R
Abstract
An optimized synthesis of enantiopure (2R)-1,2-dioctanoyloxy- and (2R) 1,2-dipalmitoyloxypropane-thiophospho-(1 D-myo-inositol) is reported starting from R-glycidol and the readily available ID-1-terr-butyldiph enylsilylmva-inositol. The key synthesis of the phosphothiolester bond is carried out by the phosphoramidite chemistry. (C) 1997 Elsevier Sc ience Ltd.