IN-VIVO STUDIES OF HEPATOBILIARY EXCRETION OF BILIRUBINS

Authors
MORA ME BARI SE AWRUCH J
Citation
Me. Mora et al., IN-VIVO STUDIES OF HEPATOBILIARY EXCRETION OF BILIRUBINS, Bioorganic & medicinal chemistry letters, 7(10), 1997, pp. 1249-1254
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
10
Year of publication
1997
Pages
1249 - 1254
Database
ISI
SICI code
0960-894X(1997)7:10<1249:ISOHEO>2.0.ZU;2-1
Abstract
Hepatic metabolism of synthetic biliverdins -ethyl-1,19,21,24-tetrahyd ro-2,8,13,17-tetramethyl - 1,19-dioxobilin-3,7,12-tripropionic acid (6 ) and coprobiliverdin II beta (7) - substrates in vitro of biliverdin reductase - showed that increasing hydrophilicity of bilirubins leads to their biliary excretion without conjugation. (C) 1997 Elsevier Scie nce Ltd.