Molecular pathology of allergic disease - I: Lower airway disease

Asthma is a complex disorder associated with eosinophil infiltration and th e activation of T lymphocytes within the airways, Recent advances in the pa thophysiologic mechanisms of asthma point to the importance of eosinophil-b asophil progenitor cells and a family of transcription factors that underli e the development of T-H(2)-type responses. Further research is needed to a ddress the development of chronic inflammatory changes, the role of profibr otic cytokines, and especially their reliance on eosinophils in the lungs.