INCORPORATION OF CONFORMATIONALLY CONSTRAINED PHENYLALANINE DERIVATIVES TIC, SIC, HIC AND NIC INTO A CHOLECYSTOKININ-B GASTRIN RECEPTOR ANTAGONIST/

Authors
GIBSON SE GUILLO N KALINDJIAN SB TOZER MJ
Citation
Se. Gibson et al., INCORPORATION OF CONFORMATIONALLY CONSTRAINED PHENYLALANINE DERIVATIVES TIC, SIC, HIC AND NIC INTO A CHOLECYSTOKININ-B GASTRIN RECEPTOR ANTAGONIST/, Bioorganic & medicinal chemistry letters, 7(10), 1997, pp. 1289-1292
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
10
Year of publication
1997
Pages
1289 - 1292
Database
ISI
SICI code
0960-894X(1997)7:10<1289:IOCCPD>2.0.ZU;2-D
Abstract
The preparation and biological properties of a conformationally constr ained series of cholecystokinin-B/gastrin receptor ligands are describ ed. The 9-membered ring (Nic) derivative was found to be as active at these receptors as an unconstrained phenylalanine analogue. (C) 1997 E lsevier Science Ltd.