Transdermal electromotive multi-drug administration for Peyronie's disease: Preliminary results

The purpose of this study was to clarify the actual therapeutic potential o f a new transdermal drug delivery system (electromotive drug administration ; EMDA) for selected patients with Peyronie's disease. Forty patients with Peyronie's disease were treated by electromotive administration of the 3-dr ug association orgotein-dexamethasone-lidocaine in a double-blind, placebo- controlled, partial crossover study (study 1). Another 25 patients were tre ated by EMDA with a combination of verapamil-dexamethasone in an uncontroll ed study (study 2). Treatment sessions lasted 20 minutes each and took plac e 3 times a week for 3 weeks with a current of 3 mA. Patients were assessed before treatment and at 1- and 3-month follow-up examinations. Assessments were based on sexual history, physical examination, and dynamic color Dopp ler ultrasonographic results. Adverse effects of EMDA were not reported. In study 1, the clinical results observed after treatment proved to be signif icantly better than those of the placebo. Penile pain disappeared in all pa tients in both studies. Penile lesion (nodule or plaque) either disappeared or significantly improved in 79% and 90% of patients treated by the 3- and 2-drug association, respectively. The improvement of penile deformity also was notable although it did not match the effect observed on penile nodule s or plaque (62% and 88%, in studies 1 and 2, respectively). In both studie s, more than 80% of patients reported a definite amelioration of penile rig idity, which paralleled the improvement of penile dynamic color Doppler ult rasonographic parameters. Overall, the combination of verapamildexamethason e achieved better clinical results than the 3-drug combination. Electromoti ve drug administration is a novel technique capable of safely achieving sat isfactory results in selected patients with Peyronie's disease not only in terms of improvement of patient's symptoms but also due to the reduced need for penile surgery.