PF1163A and B, new antifungal antibiotics produced by Penicillium sp I. Taxonomy of producing strain, fermentation, isolation and biological activities

Two novel antifungal antibiotics, PF1163A and B, were isolated from the fer mentation broth of Penicillium sp. They were purified from the solid cultur es of rice media using ethyl acetate extraction, silica gel and Sephadex LH -20 column chromatographies. PF1163A and B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells. These compounds inhibited the er,ergosterol biosynthesis in Candida albicans.