PF1163A and B, new antifungal antibiotics produced by Penicilium sp II. Physico-chemical properties and structure elucidation

Authors
Sasaki, T Nose, H Hosoya, A Yoshida, S Kawaguchi, M Watanabe, T Usui, T Ohtsuka, Y Shomura, T Takano, S Tatsuta, K
Citation
T. Sasaki et al., PF1163A and B, new antifungal antibiotics produced by Penicilium sp II. Physico-chemical properties and structure elucidation, J ANTIBIOT, 53(1), 2000, pp. 38-44
Citations number
8
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
1
Year of publication
2000
Pages
38 - 44
Database
ISI
SICI code
0021-8820(200001)53:1<38:PABNAA>2.0.ZU;2-S
Abstract
The structures of new antifungal antibiotics, PF1163A and B, were elucidate d by spectroscopic analyses of the degradation products and by X-ray crysta llography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N -methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF1163B by having an additional hydroxyl group on the side chain.