GENISTEIN AND FLUORINATED ANALOGS SUPPRESS AGONIST-INDUCED AIRWAY SMOOTH-MUSCLE CONTRACTION

Authors
BOIS F DESFOUGERES A BOUMENDJEL A MARIOTTE AM BESSARD G CARON F DEVILLIER P
Citation
F. Bois et al., GENISTEIN AND FLUORINATED ANALOGS SUPPRESS AGONIST-INDUCED AIRWAY SMOOTH-MUSCLE CONTRACTION, Bioorganic & medicinal chemistry letters, 7(10), 1997, pp. 1323-1326
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
10
Year of publication
1997
Pages
1323 - 1326
Database
ISI
SICI code
0960-894X(1997)7:10<1323:GAFASA>2.0.ZU;2-F
Abstract
4'-fluoro-5,7-dihydroxyisoflavone (DHIF), 2',4'-difluoro-5,7-DHIF and 3',4'-difluoro-5,7-DHIF were synthesized as analogs of the naturally o ccuring 5,7,4'-trihydroxyisoflavone (genistein). On guinea-pig trachea , genistein exhibited potent relaxant effect on strips precontracted w ith acetylcholine, KCl and histamine and a potent inhibitory effect on KCl-induced contraction. Fluorinated compounds showed less activity. (C) 1997 Elsevier Science Ltd.