THE ROLE OF ARGININE IN THE BINDING OF LTD4 ANTAGONISTS TO CYSLT(1) RECEPTORS OF GUINEA-PIG LUNG

Authors
ZHANG MQ ZWAAGSTRA ME NEDERKOORN PHJ TIMMERMAN H
Citation
Mq. Zhang et al., THE ROLE OF ARGININE IN THE BINDING OF LTD4 ANTAGONISTS TO CYSLT(1) RECEPTORS OF GUINEA-PIG LUNG, Bioorganic & medicinal chemistry letters, 7(10), 1997, pp. 1331-1336
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
10
Year of publication
1997
Pages
1331 - 1336
Database
ISI
SICI code
0960-894X(1997)7:10<1331:TROAIT>2.0.ZU;2-5
Abstract
Using the chemical masking agent phenylglyoxal, we have selectively bl ocked the arginine residues in leukotriene cysLT(1) receptors of guine a pig lung preparations. This treatment resulted in the markedly decre ased affinity of LTD4 antagonists to the receptor without affecting th e affinity of LTD4 itself. Our results indicate that LTD4 and its anta gonists may have different modes of interaction with the cysLT(1) rece ptor. (C) 1997 Elsevier Science Ltd.