MODELIZATION, SYNTHESIS AND ANTI-HIV ACTIVITIES OF N,N,N',N'',N'''-PENTAKISTETRAAZAMACROCYCLES SALTS DERIVATIVES

Authors
TRABAUD C DESSOLIN J VLIEGHE P BOUYGUES M CHERMANN JC CAMPLO M KRAUS JL
Citation
C. Trabaud et al., MODELIZATION, SYNTHESIS AND ANTI-HIV ACTIVITIES OF N,N,N',N'',N'''-PENTAKISTETRAAZAMACROCYCLES SALTS DERIVATIVES, Bioorganic & medicinal chemistry letters, 7(10), 1997, pp. 1353-1358
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
10
Year of publication
1997
Pages
1353 - 1358
Database
ISI
SICI code
0960-894X(1997)7:10<1353:MSAAAO>2.0.ZU;2-1
Abstract
The syntheses and the anti-HIV activities of new N,N,N',N '',N'''-pent akis-tetraazamacrocyles salts analogues are described. From computer m odeling studies, it was found that zinc coordination capacity of these pentakis derivatives was larger than the one of the corresponding tet rakis analogues. This suggest that a metal chelation energy could be a criteria to design novel anti-HIV polyazamacrocyles. (C) 1997 Elsevie r Science Ltd.