Association of KM genotype with bullous pemphigoid

Association of kappa light chain immunoglobulin allotypes with bullous pemp higoid was examined in 101 Caucasian patients. Km alleles were determined b y polymerase chain reaction amplification followed by restriction enzyme di gestion. The frequency of Km(3)/Km(1,2) kappa light-chain genotype was foun d to be significantly associated with the disease, while that of the Km(3) homozygous genotype was significantly higher in patients with both anti-BPA G1 and anti-BPAG2 autoantibodies. (C) 2000 Academic Press.