An imaged laser speckle strain gauge that yields strain rates directly is d
escribed for vascular applications. The strain gauge does not rely upon cro
ss correlations between a reference image and subsequent strain-modulated i
mages as most current speckle interferometric methods do. Instead, it relie
s upon a two-dimensional frequency transform of "stacked speckle histories"
which are time series of one-dimensional views of the speckle patterns arr
anged into a spatio-temporal array such that space is along the abscissa an
d time is along the ordinate. The tilt of the stacked speckle histories is
related to the time rate of speckle pattern shift, The strain gauge is sens
itive only to in-plane strains. Strain rates of 30.1 +/- 3.2 and 24.83 +/-
2.1 mu epsilon/s were evaluated in vitro on a fresh human tibial artery and
rat inferior vena cava, respectively. The total strains measured were 21.6
and 19.86 mu epsilon, respectively. This is at least one order of magnitud
e more sensitive than other current soft-tissue strain measurement techniqu
es. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-366
8(00)00101-5].