Selective genotyping to detect quantitative trait loci for multiple traitsin outbred populations

Selective genotyping (i.e., genotyping of individuals that are extreme for a quantitative trait) has been undertaken in many studies but has usually b een limited to one trait of interest. This paper outlines the implications of selective genotyping when applied to a daughter design. Formulas are pre sented that enable unbiased estimation of QTL effects for the selectively g enotyped and correlated traits. Formulas were verified using simulation. Fu rther, formulas are presented to enable power calculations to be undertaken for the selectively genotyped trait and correlated traits. These algorithm s are demonstrated with a numerical example.