Endothelial cell and stromal antigens in human periapical granulation tissue

Periapical granulation tissue consists of vasculature of varying sizes and types, infiltrating cells, and other stromal elements. We examined the diff erential expression of endothelial and stroma antigens in this tissue to de termine their tissue distribution in order to obtain hints on their functio ns. Some of the antigens examined were present only in the endothelial lini ng of vasculature, including high endothelial venules (e.g. CD31 and CD105) , whereas others were more widely expressed by both vascular and stromal el ements (e.g. CD29, CD63, CD44, and CD151), Immunohistochemical analysis usi ng monoclonal antibodies specific to certain tissue compartments revealed t he tissue architecture more precisely and the expression of certain antigen s in the tissue suggested special roles for these antigens, Tissue distribu tion of CD63, CD143, CD147, and CD151 in periapical granulation tissue is f irst reported in the present study.