ASYMMETRIC BIOREDUCTION OF CYCLOHEXYLPHENYL KETONE TO ITS CORRESPONDING ALCOHOL (-MAGNOLIAE MY-1785()CYCLOHEXYLPHENYL ALCOHOL BY THE YEAST CANDIDA)

Authors
CHARTRAIN M MATHRE D REAMER RA PATEL S SHINKAI I GREASHAM R
Citation
M. Chartrain et al., ASYMMETRIC BIOREDUCTION OF CYCLOHEXYLPHENYL KETONE TO ITS CORRESPONDING ALCOHOL (-MAGNOLIAE MY-1785()CYCLOHEXYLPHENYL ALCOHOL BY THE YEAST CANDIDA), Journal of fermentation and bioengineering, 83(4), 1997, pp. 395-396
Citations number
8
Categorie Soggetti
Food Science & Tenology","Biothechnology & Applied Migrobiology
Journal title
Journal of fermentation and bioengineering → ACNP
ISSN journal
0922338X
Volume
83
Issue
4
Year of publication
1997
Pages
395 - 396
Database
ISI
SICI code
0922-338X(1997)83:4<395:ABOCKT>2.0.ZU;2-Y
Abstract
The screening of 129 fungal and yeasts strains yielded Candida magnoli ae MY 1785 as a suitable biocatalyst for the asymmetric bioreduction o f cyclohexylphenyl ketone to its corresponding alcohol. Preparative am ounts of pure alcohol were prepared and purified. Polarimetry and chir al HPLC analyses indicated that C. magnoliae produced the (+) cyclohex ylphenyl alcohol with an enantiomeric excess of 75%. A 55% bioconversi on yield was achieved at the preparative scale.