RESOLUTION OF THE ENANTIOMERS OF VERAPAMIL AND GALLOPAMIL BY CHIRAL LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

Authors
RUSTICHELLI C FERIOLI V GAMBERINI G
Citation
C. Rustichelli et al., RESOLUTION OF THE ENANTIOMERS OF VERAPAMIL AND GALLOPAMIL BY CHIRAL LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY, Chromatographia, 44(9-10), 1997, pp. 477-483
Citations number
22
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Chromatographia → ACNP
ISSN journal
00095893
Volume
44
Issue
9-10
Year of publication
1997
Pages
477 - 483
Database
ISI
SICI code
0009-5893(1997)44:9-10<477:ROTEOV>2.0.ZU;2-6
Abstract
An HPLC-CSP method has been developed for the separation of enantiomer s of verapamil and gallopamil using the improved version of the alpha( 1)-acid glycoprotein, chiral stationary phase as selector with a volat ile mobile phase. The results of the investigation provide the conditi ons which allow direct coupling to a mass spectrometer. In addition, t he simultaneous enantioseparation of both the enantiomeric pairs of ve rapamil and gallopamil was achieved.