Solid phase synthesis of peptide aldehyde protease inhibitors. Probing theproteolytic sites of hepatitis C virus polyprotein

Authors
Ede, NJ Eagle, SN Wickham, G Bray, AM Warne, B Shoemaker, K Rosenberg, S
Citation
Nj. Ede et al., Solid phase synthesis of peptide aldehyde protease inhibitors. Probing theproteolytic sites of hepatitis C virus polyprotein, J PEPT SCI, 6(1), 2000, pp. 11-18
Citations number
18
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF PEPTIDE SCIENCE
ISSN journal
10752617 → ACNP
Volume
6
Issue
1
Year of publication
2000
Pages
11 - 18
Database
ISI
SICI code
1075-2617(200001)6:1<11:SPSOPA>2.0.ZU;2-O
Abstract
The solid phase synthesis of a set of peptide aldehydes derived from the NS 5A/NS5B junction of hepatitis C virus (HCV) viral polyprotein is demonstrat ed using an oxazolidine linker and the Multipin(TM) method. Deletion of the P6 and P5 residues results in a dramatic loss of inhibitory activity. Copy right (C) 2000 European Peptide Society and John Wiley & Sons, Ltd.