Antitumoral activity of new pyrimidine derivatives of sesquiterpene lactones

Sesquiterpene lactones display a wide variety of biological effects such as antiviral, antiinflammatory and cytotoxic activity. In previous studies so me derivatives of sesquiterpene lactones were prepared to be tested as anti viral and/or cytoxic agents. In the present report we describe the effects of seven modified sesquiterpene lactones on the proliferation of several ca ncer cell lines. We demonstrated antitumoral activity of two of them: III ( JLNZ-106) and IV (EDAG-IV-Sme) in HeLa, C-33, CALO, INBL, VIPA, SW480, SW62 0, MCF-7 and CHO cancer cell lines. Compounds III (JLNZ-106) and IV (EDAG-I V-Sme-IV) presented cytotoxic activity (IC50) by inhibiting the incorporati on of C-14-thymidine to DNA. These experiments suggest that derivatives III and IV should inhibit DNA replication in cancer cell lines.