Competitive binding of the anticancer drug titanocene dichloride to N,N-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for Ti-IV uptake and release by transferrin

Authors
Guo, ML Sadler, PJ
Citation
Ml. Guo et Pj. Sadler, Competitive binding of the anticancer drug titanocene dichloride to N,N-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for Ti-IV uptake and release by transferrin, J CHEM S DA, (1), 2000, pp. 7-9
Citations number
33
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
ISSN journal
03009246 → ACNP
Issue
1
Year of publication
2000
Pages
7 - 9
Database
ISI
SICI code
0300-9246(2000):1<7:CBOTAD>2.0.ZU;2-G
Abstract
H-1 and P-31 NMR studies show that in aqueous solution the anticancer agent titanocene dichloride (Cp2TiCl2) binds selectively to N,N'-ethylenebis(o-h ydroxyphenylglycine) (H(4)ehpg) at neutral pH, but preferentially to adenos ine triphosphate (ATP) at pH* values below 5.1; intermolecular Ti-IV transf er from [Ti-IV(ehpg)(H2O)] to ATP occurs at acidic pH values.