Synthesis of novel hypotensive aromatic thiocarbamate glycosides

Citation
R. Saleem et J. Meinwald, Synthesis of novel hypotensive aromatic thiocarbamate glycosides, J CHEM S P1, (3), 2000, pp. 391-394
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
3
Year of publication
2000
Pages
391 - 394
Database
ISI
SICI code
0300-922X(2000):3<391:SONHAT>2.0.ZU;2-E
Abstract
Syntheses of hypotensive thiocarbamate glycosides from Moringa oleifera are described. The route involves, first, the condensation of the sugar moiety with p-hydroxybenzonitrile to give glycoside 2, then subsequent reduction of 2 to the glycosidic benzylamine 3, which is then converted into isothioc yanate 6. Finally, alcoholysis of 6 gives the desired thiocarbamate glycosi des.