PHARMACOKINETICS OF SERTINDOLE AND DEHYDROSERTINDOLE IN VOLUNTEERS WITH NORMAL OR IMPAIRED RENAL-FUNCTION

Objective: To study the effect of renal impairment on the pharmacokine tics of sertindole. Methods: A single 4 mg oral dose of sertindole was given to normal subjects (n = 6) and subjects with various degrees of impaired renal function (n = 18) classified into mild, moderate, and severe/hemodialysis based on their creatinine clearance). The relation ships between the pharmacokinetic parameters and the degree of renal i mpairment were investigated using regression analysis with creatinine clearance as an explanatory variable along with body weight. Subjects were also genotyped for CYP2DG-A or 2D6-B mutations. Results: The mean CL/f and t(1/2) values of sertindole ranged from 14 to 31 l.h(-1) and from 73 to 93 h, respectively, and were not significantly related to creatinine clearances. There was no indication of any influence of cre atinine clearance on the fraction of sertindole (0.994-0.995) binding to plasma proteins. The total fraction of the sertindole dose removed by dialysis was less than 0.1%. Subjects with B/B genotype (n = 2) for CYP2D6 were associated with a distinctly lower clearance of sertindol e (6.3 vs 25.3 1.h(-1)) than subjects with wt/wt genotype for CYP2D6. Conclusions: Since the pharmacokinetics of sertindole are unchanged by renal impairment, dosage adjustment does not appear to be necessary f or subjects with various degrees of renal insufficiency or subjects wi th renal failure requiring hemodialysis.