Functionalization of dimeric cholestanopyrazines at the quasi-benzylic position

Authors
Lotowski, Z Dubis, EN Morzycki, JW
Citation
Z. Lotowski et al., Functionalization of dimeric cholestanopyrazines at the quasi-benzylic position, MONATS CHEM, 131(1), 2000, pp. 65-71
Citations number
14
Categorie Soggetti
Chemistry
Journal title
MONATSHEFTE FUR CHEMIE
ISSN journal
00269247 → ACNP
Volume
131
Issue
1
Year of publication
2000
Pages
65 - 71
Database
ISI
SICI code
0026-9247(200001)131:1<65:FODCAT>2.0.ZU;2-G
Abstract
Two isomeric di-5 alpha-cholestanopyrazines were brominated with NBS/AIBN a t the quasi-benzylic positions (1 alpha or 4 alpha). The nucleophilic displ acement of bromides with methanol afforded the corresponding methoxy deriva tives. Both pyrazines gave mono- or di-N-oxides upon oxidation with m-chlor operoxybenzoic acid.