An in vivo mouse micronucleus assay on musk ketone

Musk ketone (3,5-dinitro-2,6-dimethyl-4-tert-butyl-acetophenone) was evalua ted in an in vivo mouse micronucleus assay. Male and female mice were dosed with 250, 500 or 1000 mg musk ketone/kg body weight by a single intraperit oneal injection in corn oil. Results of the assay showed that under the con ditions of this test evaluated at 24, 48 and 72 h after dosing, musk ketone did not induce a significant increase in micronucleated polychromatic eryt hrocytes in either male or female mice at any dose or any time period. Musk ketone was considered to be negative in the mouse in vivo micronucleus tes t as well as in a battery of previously published in vitro genotoxicity tes ts. Based on the total weight of evidence available, it was concluded that musk ketone does not have significant potential to act as a genotoxic carci nogen. (C) 2000 Elsevier Science B.V. All rights reserved.