IMAGING OF BRONCHIAL CARCINOID-TUMORS ASSOCIATED TO CUSHING-SYNDROME WITH IN-111-OCTREOSCAN SCINTIGRAPHY AND IMMUNOSCINTIGRAPHY WITH ANTI-CHROMOGRANIN MONOCLONAL-ANTIBODIES - REPORT OF 2 CASES

Bronchial carcinoid tumors are neuroendocrine neoplasms capable of exp ressing somatostatin receptors and of secreting neuromediators such as ACTH and chromogranins. Radiologic appearance is usually non-specific and has to be distinguished from benign pulmonary nodules and other m alignant diseases. Standard radiological techniques have Limited accur acy in the evaluation of such lesions. Radioisotopic imaging technique s may increase the specificity of diagnostic assessment. The role of i mmunoscintigraphy with anti-chromogranin A and B monoclonal antibodies (MoAbs) and of In-111-Octreoscan. scintigraphy is evaluated in two ca ses of bronchial carcinoid tumors associated to Gushing syndrome.