No induction of apoptosis by IFN-beta in human antigen-specific T cells

Authors
Zipp, F Beyer, M Gelderblom, H Wernet, D Zschenderlein, R Weller, M
Citation
F. Zipp et al., No induction of apoptosis by IFN-beta in human antigen-specific T cells, NEUROLOGY, 54(2), 2000, pp. 485-487
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
54
Issue
2
Year of publication
2000
Pages
485 - 487
Database
ISI
SICI code
0028-3878(20000125)54:2<485:NIOABI>2.0.ZU;2-H
Abstract
Interferon (IFN)-beta, the most effective immunomodulatory treatment for MS , inhibits the proliferation of myelin-specific T cells. We report that IFN -beta moderately enhances the expression of the death receptor, CD95, at th e surface of human antigen-specific T cells. However, T-cell apoptosis was not induced by IFN beta-1a or IFN beta-1b as assessed by caspase activity o r DNA fragmentation. Immunomodulation mediated by IFN-beta does not directl y involve apoptotic pathways in human T cells.