Hemodynamic changes in simple partial epilepsy: A functional MRI study

We performed functional MRI (fMRI) on a patient with a mass lesion while sh e happened to experience a simple partial seizure. We used regional T2* sig nal changes to localize seizure-related hemodynamic changes. Seizure activi ty was associated with changes in MR signal in different regions that showe d sequential activation and deactivation. Our study has shown that epilepti c activity leads to changes in cerebral hemodynamics. In selected patients, therefore, it might be possible to use fMRI as a noninvasive tool to detec t and investigate cortical patterns of activation associated with seizure a ctivity.