A number of imaging techniques have been used to investigate changes produc
ed in the brain by boxing. Most morphological studies have failed to show s
ignificant correlations between putative abnormalities on imaging and clini
cal evidence of brain damage. Fenestration of the septum pellucidum, with f
ormation of a cavum, one of the most frequent observations, does not appear
to correlate with neurological or physiological evidence of brain damage.
Serial studies on large groups may be more informative. Magnetic resonance
spectroscopy and cerebral blood flow studies have been reported in only sma
ll numbers of boxers; serial studies are not available to date.