Blepharoptosis and central nervous system abnormalities in combined valproate and hydantoin embryopathy

Purpose: To report a case of intrauterine anticonvulsant exposure with subs equent ocular adnexal manifestations. Methods: Case report. Results: An 18-month-old child with known anticonvulsant embryopathy was re ferred for the management of bilateral congenital blepharoptosis. Physical examination confirmed ocular and nonocular external manifestations of valpr oate and hydantoin embryopathies. Cavum septum pellucidum, mild sulcation d efects, and cerebellar atrophy were identified on neuroimaging. Conclusions: To our knowledge, our patient represents the second reported c ase of anomalous septum pellucidum after intrauterine valproate exposure. C linicians evaluating patients with craniofacial features associated with in trauterine valproate exposure should recognize that concomitant anomalies o f the central nervous system, including the septum pellucidum, might exist.