"Reactive filtration": Use of functionalized porous polymer monoliths as scavengers in solution-phase synthesis

Solid functionalized porous monolithic disks with reactive polymer chains g rafted to their inner pore surface have been developed for scavenging exces s reagents from reaction mixtures. A poly(chloromethylstyrene-co-divinylben zene) monolith was cut into disks and activated by graft polymerizing 4-vin yl-2,2-dimethylazlactone to its pore surface. In contrast to the direct cop olymerization of reactive monomers, grafting increases the accessibility of the reactive groups. Application of the reactive disks is demonstrated in the scavenging of excess amines from reaction mixtures in different solvent s.