Enantioselective synthesis of the [6,6] spiroketal core of reveromycin A

Citation
Ke. Drouet et al., Enantioselective synthesis of the [6,6] spiroketal core of reveromycin A, ORG LETT, 2(2), 2000, pp. 207-210
Citations number
35
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
2
Year of publication
2000
Pages
207 - 210
Database
ISI
SICI code
1523-7060(20000127)2:2<207:ESOT[S>2.0.ZU;2-7
Abstract
Reveromycin A (1) belongs to a family of microbial polyketides with unusual structural features and biological activities. The structure of 1 is compo sed of a [6,6] spiroketal core decorated with highly unsaturated side chain s, As a prelude to the synthesis of 1, we present herein a short, efficient , and enantioselective synthesis of the C9-C21 fragment 5 (spiroketal core) of reveromycin A.