Reveromycin A (1) belongs to a family of microbial polyketides with unusual
structural features and biological activities. The structure of 1 is compo
sed of a [6,6] spiroketal core decorated with highly unsaturated side chain
s, As a prelude to the synthesis of 1, we present herein a short, efficient
, and enantioselective synthesis of the C9-C21 fragment 5 (spiroketal core)
of reveromycin A.