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Model study for a general approach to morphine and noroxymorphone via a rare heck cyclization
Authors
Frey, DA
Duan, CM
Hudlicky, T
Citation
Da. Frey et al., Model study for a general approach to morphine and noroxymorphone via a rare heck cyclization, ORG LETT, 1(13), 1999, pp. 2085-2087
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 →
ACNP
Volume
1
Issue
13
Year of publication
1999
Pages
2085 - 2087
Database
ISI
SICI code
1523-7060(199912)1:13<2085:MSFAGA>2.0.ZU;2-Z
Abstract
[GRAPHICS] beta-Bromoethylbenzene was converted to the pentacycle 6 in 11 steps. The k ey features of this model were the toluene dioxygenase catalyzed production of diol 13 and the stereospecific Heck closure of 5 to 6.