Regioselective Rh-catalyzed allylic amination/ring-closing metathesis approach to monocyclic azacycles: Diastereospecific construction of 2,5-disubstituted pyrrolines
Pa. Evans et Je. Robinson, Regioselective Rh-catalyzed allylic amination/ring-closing metathesis approach to monocyclic azacycles: Diastereospecific construction of 2,5-disubstituted pyrrolines, ORG LETT, 1(12), 1999, pp. 1929-1931
[GRAPHICS]
Regioselective rhodium-catalyzed allylic amination followed by ring closing
metathesis, using the Grubbs' catalyst, provides an expeditious route to m
onosubstituted azacycles, The enantiomerically enriched allylamine 1 can al
so be resubjected to the reaction sequence with (R) and (S)-2b to facilitat
e the diastereospecific construction of 2,5-disubstituted pyrrolines 3/4.