Regioselective Rh-catalyzed allylic amination/ring-closing metathesis approach to monocyclic azacycles: Diastereospecific construction of 2,5-disubstituted pyrrolines

Authors
Evans, PA Robinson, JE
Citation
Pa. Evans et Je. Robinson, Regioselective Rh-catalyzed allylic amination/ring-closing metathesis approach to monocyclic azacycles: Diastereospecific construction of 2,5-disubstituted pyrrolines, ORG LETT, 1(12), 1999, pp. 1929-1931
Citations number
33
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
12
Year of publication
1999
Pages
1929 - 1931
Database
ISI
SICI code
1523-7060(199912)1:12<1929:RRAAMA>2.0.ZU;2-6
Abstract
[GRAPHICS] Regioselective rhodium-catalyzed allylic amination followed by ring closing metathesis, using the Grubbs' catalyst, provides an expeditious route to m onosubstituted azacycles, The enantiomerically enriched allylamine 1 can al so be resubjected to the reaction sequence with (R) and (S)-2b to facilitat e the diastereospecific construction of 2,5-disubstituted pyrrolines 3/4.