Asymmetric catalytic Friedel-Crafts reaction of silyl enol ethers with fluoral: A possible mechanism of the Mukaiyama-Aldol reactions

Authors
Ishii, A Kojima, J Mikami, K
Citation
A. Ishii et al., Asymmetric catalytic Friedel-Crafts reaction of silyl enol ethers with fluoral: A possible mechanism of the Mukaiyama-Aldol reactions, ORG LETT, 1(12), 1999, pp. 2013-2016
Citations number
49
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
12
Year of publication
1999
Pages
2013 - 2016
Database
ISI
SICI code
1523-7060(199912)1:12<2013:ACFROS>2.0.ZU;2-8
Abstract
[GRAPHICS] The catalytic asymmetric Friedel-Crafts reaction of silyl enol ethers with fluoral proceeds under Mukaiyama-aldol conditions to give silyl enol ether products. The sequential diastereoselective reactions of the resultant sily l enol ethers with electrophiles provide highly enantiopure functionalized organofluorine compounds of material and pharmaceutical interest.