Synthesis of modified oligodeoxyribonucleotides on a solid-phase support via derivatization of a selectively revealed 2 '-amino-2 '-deoxyuridine

Authors
Hwang, JT Greenberg, MM
Citation
Jt. Hwang et Mm. Greenberg, Synthesis of modified oligodeoxyribonucleotides on a solid-phase support via derivatization of a selectively revealed 2 '-amino-2 '-deoxyuridine, ORG LETT, 1(12), 1999, pp. 2021-2024
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
1
Issue
12
Year of publication
1999
Pages
2021 - 2024
Database
ISI
SICI code
1523-7060(199912)1:12<2021:SOMOOA>2.0.ZU;2-9
Abstract
[GRAPHICS] High yields of oligodeoxyribonucleotides modified at the C2'-position of si te specifically incorporated 2'-amino-2'-deoxyuridine are obtained by photo lytically unmasking the nucleophile in an otherwise protected solid-phase s upport-bound biopolymer.