Risk factors for hyperlipidemia in long-term pediatric renal transplant recipients

Hyperlipidemia (HL) is a common problem in adult renal transplant (TP) reci pients, contributing to an increased risk of cardiovascular disease and chr onic TP nephropathy. There are multiple causes of HL post renal TP in adult patients, including pre TP HL, immunosuppressive agents, renal dysfunction , hypoalbuminemia secondary to nephrotic syndrome, obesity, and conditions that lead to end-stage renal disease (ESRD). We evaluated the incidence and risk factors of HL in 62 pediatric renal TP recipients (15.4+/-4.2 years, range-3.0-22.3 years) with long-term (6.7+/-3.1 years) functioning [glomeru lar filtration rate (GFR) 66.7+/-23.2 ml/min per 1.73 m(2)] allografts. The mean serum cholesterol (C) level was 205.5+/-43.6 mg/dl. Thirty-two patien ts (51.6%) exhibited elevated serum C levels. The mean serum triglyceride ( TG) level was 157.3+/-88.4 mg/dl. Serum TG levels were elevated in 32 patie nts (51.6%). In patients with elevated serum levels of either C or TG, the mean low-density lipoprotein level (LDL) was 138.6+/-44.1 mg/dl (normal <13 0 mg/dl) and the high-density lipoprotein (HDL) level 54.6+/-15.9 mg/dl (no rma1>34 mg/dl). Of those patients studied, 45.5% had high LDL levels, where as 9.1% exhibited low HDL levels. The two risk factors for elevated serum C levels in our patient population were pre-TP HL and increased years since TP. The only risk factor for elevated serum TG levels was reduced GFR. A fa mily history of HL had a significant deleterious impact upon serum levels o f C (P=0.01), but did not affect serum TG levels (P=0.7). Years on dialysis prior to TP, history of prior TP, gender, body mass index, and disease lea ding to ESRD had no influence upon the development of post-TP HL, We conclu de that post-renal TP HL is a significant problem in pediatric renal TP rec ipients.