BREAST-CARCINOMA WITH MYELOID METAPLASIA - A CASE-REPORT

A 49 year-old female had been suffering from primary myelofibrosis sin ce February 1987 without receiving any treatment. In 1994, a breast ma ss was detected. Breast tumor biopsy revealed tubular carcinoma with i ntraductal components and multinucleated giant cells in the loose and myxoid stroma. The giant cells were thought to be megakaryocytes becau se both Factor VIII and platelet glycoprotein GP IIIa were detected in their cytoplasm. While additional mastectomy specimens and the axilla ry lymph nodes also revealed prominent myeloid metaplasia, there was n o proliferation of the cancer cells. Granulocytic series stained for c hloroacetate esterase and very few erythrocytic series were observed. This is the first case in which breast carcinoma and myeloid metaplasi a coexisted in the same breast tumor.