Transgenic models as tools for studying the regulation of human renin expression

Transgenic mice and rats have become popular tools to study the regulation of gene expression and the consequences of protein over-production. Over th e past decade, numerous transgenic models have been developed to study the mechanisms of human renin gene expression and the participation of the reni n-angiotensin system in the development of hypertension. Herein we will pro vide an overview: of what has been learned from the use of transgenic model s for studying the human renin gene. (C) 2000 Elsevier Science B.V. All rig hts reserved.