Polymorphism of angiotensinogen II T174M gene and cardiovascular diseases in the Moscow population

Groups of patients with myocardial infarction (MI) and left ventricular hyp ertrophy (LVH) (n = 45 and n = 53, respectively) and a sample of healthy in dividuals from the Moscow population (n = 60) were examined for T174M polym orphism of AGT gene (replacement of methionine for threonine at position 17 4 of the correspondent amino acid sequence). In MI patients, the content of TT genotypes and T allele was significantly lower than in the control grou p (57.8 vs. 80% and 67.9 vs. 89.2%, respectively), whereas the proportion o f M allele and TM heterozygotes was increased (32.1 vs. 10.8% and 37.8 vs. 18.3%, respectively). In patients with LVH, the proportion of TT genotype ( 64.2%) and T allele (77.4%) was also lower than in the control group, where as the frequency of M allele was increased (22.6%). Our results suggest tha t the T174M polymorphism of AGT gene is associated with MI and LVH in the M oscow population.